The role of the imbalance of regulatory cytokines in the blood of rats under conditions of chronic immobilization stress, compared with the control, in the implementation of immune mechanisms of pancreatic damage was considered, where it was established: a predominant increase in the content of IL-12, a decrease in IL-4 in rats, which indicates participation of both specific (Th 1) and activation of nonspecific (macrophage) cellular immunity, which is possibly associated with increased production of Th1-lymphokines that stimulate excessive migration of macrophages-effector cells, immune response modulators, sources of regulatory cytokines to the site of damage where an excess of cytokines can potentiate the development of chronic pancreatitis in the future